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Genes & gene fragments

Understanding the importance of 3’ UTR mutations in cancer research

Citation summary: While mostly unexplored and given significantly less attention than coding sequence (CDS) and 5’ untranslated regions (UTR), 3’ UTR somatic mutations affect mRNA stability and translation, making them important subjects to study for cancer researchers to better understand cancer progression. This DECODED summarizes the efforts of researchers from the University of Washington and Fred Hutchinson Cancer Center to characterize 3’ UTR somatic mutations.